T2D-associated phenotypes linked to chromosome 15 have been described in a number of linkage studies from other groups, namely in the insulin deficient (AkitaxA/J)F2 mice, carriers of diabetes mutation (BKSxDBA/2)F2 mice, (A/WySnJxCAST/Ei) mice and (NZO/HlLtxNON/Lt) animals [20,24,25,26]. The gene discussed is INS; the disease is type 2 diabetes mellitus.