Moreover, our study proposed some new perspectives to study myocardial lipotoxicity and reported the inhibitory effect of CAN on the p65/COX-2/iNOS signaling pathway and ferroptosis indicators, which may provide more data support for the application of CAN in cardiovascular diseases and new ideas for the treatment of patients with DCM. Here, PTGS2 is linked to Crouzon syndrome-acanthosis nigricans syndrome.