Many clinical studies and some meta-analyses have recently confirmed that some individuals apparently free from cardiac disease have hs-cTnI or hs-cTnT concentrations in the third tertile of the distribution values of biomarkers (i.e., still below the cut-off value of 99th percentile URL), who are at higher risk of earlier cardiac or non-cardiac mortality and/or rapid progression to heart failure [15,16]. The gene discussed is TNNI3; the disease is heart disorder.