Recently, McKechnie et al. [231] evaluated using multiple regression analysis the relationship of activation of natriuretic peptide system (evaluated by NT-proBNP assay) with baseline inflammation (evaluated by CRP and IL-6 assays) and incidence of HF in 3569 men followed for 16.3 years (aged 40–59 years at enrollment) and without prevalent myocardial infarction or HF. This evidence concerns the gene IL6 and hydrops fetalis.