F2RL1 and Alzheimer disease: Other AD-associated cytokines such as Il-13 and thymic stromal lymphopoietin (TSLP) can act similarly with protease-activated receptor-2 (PAR2)-regulated TSLP secretion of keratinocytes regulated by calcium release-activated calcium modulator 1/nuclear factor of activated T-cells (ORAI1/NFAT) calcium signalling pathway, being an example showing that keratinocytes can also directly communicate with sensory neurons [42].