Compared to obese nonT2DM individuals, in obese class III (OBIII) patients, T2DM induced higher serum levels of the following 7 proteins, which are all involved in glucose metabolism, satiety and inflammation (Figure 1): ghrelin, glucagon like-peptide-1 (GLP-1), glucagon, B-cell activating factor (BAFF), chitinase 3-like, tumor necrosis factor receptor 1 (TNF-R1) and tumor necrosis factor receptor 2 (TNF-R2) and matrix metalloproteinase-3 (MMP-3). This evidence concerns the gene TNFRSF1A and type 2 diabetes mellitus.