TNFRSF1A and obesity due to melanocortin 4 receptor deficiency: However, unlike in AT composition where metabolic, oxidation, coagulation and inflammatory proteins were altered, mainly inflammatory cytokines such as IL-8, TNFSF13 B, TNFR1 and TNFR2 [40] and the metalloproteinase MMP-3 were affected in the serum of diabetic individuals, independently of the presence of obesity.