AD causative mutations in PSEN1 (p.Ala246Glu rs63750526, exon 9 deletion (ΔE9) p.Ser290Cys;Thr291_Ser319del rs63750219) result in decreased HSPA5 mRNA or BiP protein levels after incubation of transfected SK-N-SH neuroblastoma cells with tunicamycin. The gene discussed is HSPA5; the disease is Alzheimer disease.