SIGMAR1 and Alzheimer disease: Sigma1R ligands with agonist activity pridopidine [176], T-817 MA [193], ANAVEX 3-71 [194,195], fluvoxamine [157] and Sigma1R positive modulator OZP002 [186] showed neuroprotective properties in transgenic AD models, similarly to AD models induced by the administration of Aβ peptides (Table S1).