When the targeted nanoparticles are incubated with PSMA-positive prostate cancer C4-2 cells, the endocytosis efficiency of PSMA-targeted PFP@IR780@PTX@liposomes was significantly higher than that of the untargeted group, indicating that nanoparticles could aggregate into prostate tumor cells actively and efficiently through PSMA-targeting modification to achieve their functions. Here, FOLH1 is linked to prostate cancer.