EGR2 and pancreatic insulinoma: Figure 2B shows that Egr-1-3 proteins are expressed in pancreatic β-cells and INS-1 insulinoma cells [10]. Biosynthesis of Egr-2 is induced after stimulation of insulinoma cells with a synthetic agonist for voltage-gated Ca2+ channels [11], suggesting that glucose stimulation may also affect Egr-2 expression levels.