Therefore, for correct SFP diagnosis, it is important to evaluate the patient’s previous allergic anamnesis and indirect epidemiologic signs, and to perform a molecular allergology examination, such as ImmunoCAP (Immuno Solid-phase Allergy Chip) ISAC assay, MeDALL allergen-chip assay, or highly sensitive ELISA-based assay, which will help rule out a true IgE-associated allergy to fish and seafood associated with sensitization to parvalbumins [14,15,16,17]. Here, IGHE is linked to allergic disease.