The main roles in the molecular mechanisms of SFP are not only dose-dependent exogenous histamine intoxication but also the complement system, NET activation, NF-κB, etc. Important in the development of SFP are associated diseases and disorders, such as IBS, IBD, GERD, mast cell activation syndrome, intestinal mastocytosis, and others. The gene discussed is NFKB1; the disease is gastroesophageal reflux disease.