The latter promotes the release of soluble factors such as TGF-β, VEGF (vascular endothelial growth factor) and its analogue BV8, bFGF (basic fibroblast growth factor), MMP-9 (matrix metalloproteinase-9) and osteopontin, which favors tumor cell invasion within the bone, as it occurs for the metastases of several solid tumors, or the growth of HGOSs. This evidence concerns the gene FGF2 and neoplasm.