CCL22 and neoplasm: M2 TAMs promote tumorigenesis [14], stemness maintenance [15], HGOS metastatization [16] and immunosuppression on the activity of tumor-infiltrating lymphocytes (TILs) by releasing immunosuppressive soluble factors as IL-10, TGF-β2 (transforming growth factor-β2) and CCL22 (chemokine (C-C motif) ligand 22) [2].