TGFB1 and neoplasm: The latter promotes the release of soluble factors such as TGF-β, VEGF (vascular endothelial growth factor) and its analogue BV8, bFGF (basic fibroblast growth factor), MMP-9 (matrix metalloproteinase-9) and osteopontin, which favors tumor cell invasion within the bone, as it occurs for the metastases of several solid tumors, or the growth of HGOSs.