CUBN and amyotrophic lateral sclerosis: The PD1* thermogram exhibited unique features: it was highly cooperative; the Igs transition was shifted to 69.62 °C compared to 68.78 °C for the healthy one; and its heat capacity was drastically reduced to 0.09, i.e., more than two times lower than the healthy cPIgs (0.21), resulting in a cPHSA/cPIgs ratio of 5, the highest among all studied PD and ALS cases, and 2.5 times higher than the healthy one (Table 2).