CUBN and amyotrophic lateral sclerosis: Furthermore, the ratio of the excess heat capacities of HSA and Igs transitions, cPHSA/cPIgs, varied considerably for PD and ALS cases, being drastically high for the PD1* case and for the ALS2 set, too low for the PD4* case, and in the range from 1.4–1.95 for most cases, due to different tendencies in the changes of cPHSA and cPIgs values (Table 1).