Importantly, a lower value of cPHSA is determined in PD and ALS cases than that in healthy state, although the albumin content in plasma is not reduced (Table 1 and Table 3), and of ΔHcal of most PD and ALS sets/cases (Table 2) suggesting altered binding states of a fraction of albumin and its conformation, as well as of the protein–protein interaction network. The gene discussed is ALB; the disease is Parkinson disease.