GSDMD and ocular melanoma: qPCR results showed that the mRNA levels of caspase-1, IL-18, and GSDMD were significantly higher in the SG of OM rats than in the control group (Figure 10A), (p < 0.01); after treatment with P2X4 shRNA or imperatorin, the mRNA levels of all these molecules were significantly decreased (p < 0.05).