The ELISA results showed that the serum levels of IL-1β (Figure 8a), TNF-α (Figure 8d), and IL-18 (Figure 8c) in the OM group were significantly higher than that in the control group (p < 0.05), while treatment with P2X4 shRNA or imperatorin significantly reduced the levels of the above inflammatory factors. This evidence concerns the gene IL1B and ocular melanoma.