LYAR and thalassemia: On the basis of these results, supporting a repressor role of LYAR in γ-globin gene transcription and in order to further analyze its role in the action of different HbF inducers, the expression of LYAR mRNA was quantified by RT-qPCR in ErPCs from 29 (for MTH induction) and 19 (for HU and RAPA induction) β-thalassemia patients (among which five β0-thalassemia, A/A or A/G and six β+-thalassemia G/G patients) treated with MTH, HU, and RAPA.