APOE and Alzheimer disease: The association between ApoE4 and AD risk has been also linked to the function of mitochondria-ER-associated membrane (MAM), whose tethering facilitates the transport of Ca2+ from the ER to mitochondria and the exchange of lipids, being also a molecular platform essential for NLRP3 (NOD-like receptor protein 3, or nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing protein 3) inflammasome formation, among other potential cellular roles [74].