STAR and breast cancer: Among these StAR acetylomes, point mutations of K111 and K253, acetylated frequently in ER+BC cells, to K111R (arginine) and K252R, deacetylation mimetics, resulted in suppression of E2 levels in MCF7 cells (Manna PR et al., unpublished observations and a manuscript in preparation), suggesting that StAR acetylation plays an important role in regulating E2 synthesis.