Here, only HIF-1α + GLUT1+ neutrophils were proportionally increased in PDAC tumor tissue (23.21%) compared to adjacent matched normal tissue (8.17%), while the proportion of HIF-1α + HK2+ and GLUT1 + HK2+ neutrophils was similar between the two groups (Figure 3d). This evidence concerns the gene SLC2A1 and neoplasm.