In the P48-Cre/LSL-KrasG12D mouse model that spontaneously develops pancreatic cancer through Kras-stimulated progression of PanIN lesions [34], we showed that treatment with the NP loaded with muKras siRNA significantly halted PanIN progression and altered the fibrosis of the pancreas extracellular matrix thus preventing cancer. The gene discussed is KRAS; the disease is familial pancreatic carcinoma.