Consequently, RBCs micro-vesiculation and persistence of pro-coagulant CD235a+ PS+ RBC-derived EVs in, respectively, high concentrations in peripheral blood is a result of complex pathological processes, which are under control of pro-inflammatory genes, epigenetic regulation, endocytosis by endothelial cells, and mechanical impact of altered intra-cardiac blood flow, systemic inflammation and atherosclerosis [42,43,44]. The gene discussed is GYPA; the disease is atherosclerosis.