In another study, also of a small group of volunteers (n = 14, overrepresented by women, mean age 48 years) with Cushing’s syndrome secondary to pituitary adenomas, adrenal cortex adenomas, or ectopic production of ACTH, the authors found increased platelet activation as measured by thromboxane B2 levels in the blood. Here, POMC is linked to Cushing syndrome due to macronodular adrenal hyperplasia.