Several HDACs can act to deacetylate a certain histone in different forms of cancer: H3K9 (HDAC3), H3K14 (HDAC1, HDAC3), H3K56 (HDAC1, HDAC2), H4K5 (HDAC1, HDAC2, HDAC3), H4K8 (HDAC1, HDAC2), H4K12 (HDAC1, HDAC2, HDAC3), and H4K16 (SIRT1, SIRT2, HDAC1, HDAC2, HDAC3) [94]. This evidence concerns the gene HDAC1 and cancer.