Genomic classification of cutaneous melanoma includes four main categories: BRAF-mutated melanoma (50% of all cases); RAS-mutated melanoma (25%; NRAS is the most commonly mutated); NF1-mutated melanoma (10–15%); and the triple-wild-type melanoma (10%; rare variants in KIT, GNAQ, GNA11, or translocations of kinases) [21]. The gene discussed is GNAQ; the disease is melanoma.