Fu et al. summarized the genes hypermethylated in melanoma: LINE-1, CLDN11, TERT, MGMT, KIT, TNF, MITF, RASSF6, RASSF10, GPX3, MMP-9, SYNPO2, CDKN1C, LXN, ASC/PYCARDC/PYCARD, Col11A1, SOCS1, Caspase 8, CDH1, MGMT, RAR-b2, CIITA-PIV, SOCS2, TNFRSF10C (DcR1/2), TPM1, TIMP3, CDKN2A, DPPIV, FRZB, SOCS3, THBS1, and TM [128]. The gene discussed is CDH1; the disease is melanoma.