Namely, three dysregulated miRNAs (miR-34b, miR-218, and miR-221) interact with the PD-related genes parkinsonism associated deglycase (DJ1), parkin RBR E3 ubiquitin protein ligase (PRKN), and synuclein alpha (SNCA) and modulate their functions in different PD cellular and animal models. The gene discussed is SNCA; the disease is Parkinson disease.