We found increases in the concentrations of S100A8 (2.2-fold, p = 0.024), S100A9 (1.9-fold, p = 0.017), S100A11 (1.2-fold, p = 0.007), S100A12 (1.6-fold, p = 0.007), MYD88 (1.2-fold, p = 0.008), JAK3 (1.8-fold, p = 0.009), and IQGAP1 (1.4-fold, p = 0.02) in patients with RA compared to the HCs. Here, S100A8 is linked to rheumatoid arthritis.