In Figure 5A,B, it can be seen that the S100A12 protein in sera was much more specific (area under the curve (AUC) = 0.87, p = 0.0006; and AUC = 0.83, p = 0.002, respectively) in all RA and eRA patients than the CRP level (AUC = 0,63, p = 0.215; and AUC = 0.52, p = 0,874). This evidence concerns the gene S100A12 and rheumatoid arthritis.