PINK1 and Parkinson disease: In further support of its ability to exert neuroprotective effects, we have shown that intraperitoneal administration of Forskolin (five doses over ten days) in vivo is sufficient for ameliorating motor symptoms of PD and corporeal fatigue as assessed by measuring hind limb strength and reverses degeneration of midbrain dopamine neurons in symptomatic PINK1-KO rats [46].