VASN and osteoarthritis: In addition, vasorin expression is altered in several diseases; it is higher than normal in synovial fluid of patients with osteoarthritis [64], in plasma of patients with diabetic nephropathy [65], in serum of subjects with hepatocarcinoma [66], in urinary exosomes of patients with thin basement membrane nephropathy; on the contrary, vasorin expression is lower than normal in subjects with early IgA nephropathy [67,68].