SRSF4, serine/arginine-rich splicing factor 4, interacting with heterogeneous nuclear ribonucleoproteins hnRNPG and hnRNPE2, regulates the 5’ splice site of tau exon 10; splicing misregulation could lead to frontotemporal dementia (FTD) in humans [64]. Here, MAPT is linked to frontotemporal dementia.