APOE and Alzheimer disease: Furthermore, the STRING network analysis for genes increased in both models (Figure 4B) showed that Ftl1, involved in neuroferritinopathy [110], interacts with Rpl10, a gene linked with autism progression [111], Srp9, a gene related to seizure susceptibility [69], and Apoe, a gene related to axon demyelination and impaired synapse formation in AD [112].