Pik3ca also interacts with Lrp8, a gene related to the onset of neuropsychiatric diseases, such as schizophrenia [107], Mapk8, a gene associated with reduced apoptosis in glioblastoma cells [108], and Sorl1, which is decreased in AD brains by regulating Aβ accumulation [109]. Here, PIK3CA is linked to Alzheimer disease.