Neurogenic inflammation is presumed to play an important role in the pathogenesis of migraine attacks, involving the release of various vasoactive neuropeptides such as calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP). The gene discussed is ADCYAP1; the disease is migraine disorder.