After selecting only the SSc plasma samples that were double-positive for CXCL4 and RNA (therefore containing CXCL4-RNA complexes), we calculated the correlation again with IFN-α and found that the coefficient « r » increased (rspearman = 0.77; p = 0.005; N = 12, Figure S2). This evidence concerns the gene PF4 and systemic sclerosis.