In this study, we have demonstrated for the first time that CXCL4-RNA complexes circulate in SSc blood and correlate with both IFN-I and TNF-α, two factors that are particularly upregulated in SSc and participate in disease pathogenesis [1,2,3,4,5,6,7,21,22,33]. This evidence concerns the gene PF4 and systemic sclerosis.