The first evidence of a possible link between endoglin in the kidney interstitium and the extent of chronic histological renal damage in different kidney diseases was investigated by Roy-Chaudhury et al. This study from 1997 analyzed biopsies of patients with chronic progressive renal disease and found a weak, albeit significant difference between the extent of interstitial endoglin staining in cases with mild and severe chronic histological damage [30]. Here, ENG is linked to kidney disorder.