Mechanisms of resistance to CAR-T cells are under investigation, and published data from the single-cell transcriptomic analyses of a single PC leukemia patient treated with anti-BCMA CAR-T cells have shown gene expression modification after therapy involving genes related to proliferation, cytotoxicity, and intracellular signaling pathways [160]. The gene discussed is TNFRSF17; the disease is pachyonychia congenita.