GSTM1 and G6PD deficiency: In this regard, since no Hb structural defects are usually associated with G6PD deficiency (neither in the literature nor in the specific case study), its lower structural stability should not depend on intrinsic protein differences but rather on defects associated with the cellular micro-environment, which, in the G6PD-defective case, is known to be more susceptible to oxidative stresses.