IBD is induced by the exaggerated activation of NLRs and TLRs, followed by high expression of the proinflammatory cytokines IL-6, IL-12, IL-23, and tumor necrosis factor α (TNF-α) in the colonic mucosa by innate immune cells upon their activation with TLR ligands [43,44,45]. The gene discussed is TNF; the disease is inflammatory bowel disease.