SRM and posterior cortical atrophy: Finally, the analysis of the expression of IMDH1 (gene IMDPH1) and SPEE (gene SRM), which were downregulated in LNCaP cells overexpressing miR-423-5p from the proteomic analysis, showed an opposite trend at the transcriptomic level using the TCGA-PRAD and GTEx datasets, suggesting that the lowered expression of these target proteins is mediated by the overexpression of miR-423-5p in PCa cells (Table 7).