It merits special mention that both miR-126 and miR-146a are closely linked to generally approved inflammatory and endothelial dysfunction markers, including IL-6, IL-8, TNF-α, NF-κB, VCAM-1 or interleukin 1 receptor-associated kinase 1 (IRAK1), tumor necrosis factor receptor-associated factor 6 (TRAF6) as well as they can lead to the accumulation of dysfunctional endothelial senescent cells and the shift of circulating angiogenic cells from a proangiogenic to a proinflammatory profile [194,202,203,204,205,206,207,208]. The gene discussed is IRAK1; the disease is endothelial dysfunction.