Notably, the downregulation of miR-214 and miR-190a exert a significant role in MGO-induced endothelial insulin resistance, at least in part, by increasing their specific targets, PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) levels, a negative regulator of the insulin signaling and GTPase Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), respectively [54,55]. The gene discussed is INS; the disease is Insulin resistance.