Most recently, miR-126-3p has occurred to play a crucial role in T2DM VSMC metabolic memory through the activation of MAPK/ERK pathway, enhancing the efficiency of blockers of potassium channels Kv1.3 in VSMCs, thus preventing their proliferation, migration, and vessels remodeling [132]. This evidence concerns the gene KCNA3 and type 2 diabetes mellitus.