TNF and diabetes mellitus: Several studies have indicated that aberrant expression of the let-7 miRNA family (let-7b and let-7d), miR-149-5p, and miR-190a-5p regulate inflammatory pathways in diabetes-associated endothelial injury, and restoring expression of these miRNAs, similar to downregulation of miR-34a and miR-197 may contribute to decreased TNF-α, IL-6, IL-1β, MCP-1, VCAM-1, and ICAM-1 level [75,79,80,81,82].