AKT1 and chronic kidney disease: The anti-inflammatory and anti-tumoral Atractylodes lactone extracted from the rhizome of Atractylodes macrocephala Koidz can counteract the oxidative stress associated with chronic kidney disease, reducing muscle wasting via inhibition of the phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) pathway [88].