Neurodegenerative pathologies include tauopathies (Parkinson’s disease), amyloidosis (Alzheimer’s disease), α-synucleinopathies (Levi’s bodies in Parkinson’s disease), TDP-43 (TAR DNA-binding protein 43) and SOD1 (superoxide dismutase 1) proteinopathy (amyotrophic lateral sclerosis), prionopathy and others. The gene discussed is SOD1; the disease is early-onset autosomal dominant Alzheimer disease.