A cross–sectional study by Spałkowska et al., aiming to assess ER-α, ER-β and GPER expression on melanocytes and keratinocytes of common nevi, dysplastic nevi, and healthy skin margin in 73 consecutively excised melanocytic lesions, showed, by immunochemistry analysis, the lowest ER-β expression in melanomas and dysplastic nevi, confirming a previous study of Giorgi et al. who reported a significantly lower ER-β expression in melanoma tissue compared with adjacent healthy skin [34]. This evidence concerns the gene ESR2 and melanoma.