For example, the neurotransmitter acetylcholine (ACh) can stimulate CRC cell proliferation, invasion, vascularization, and migration by binding to muscarinic receptor 3 (M3R) through activation of the epidermal growth factor receptor (EGFR), PI3K, extracellular signal-regulated kinase (ERK)1/2 and AKT pathways as well as alpha 7 nicotinic receptor (α7nAChR) through activation of Janus kinase 2 (JAK2)/Signal transducer and activator of transcription 3 (STAT3) pathway [23,24,25,26,27,28,29]. This evidence concerns the gene STAT3 and colorectal carcinoma.