This update on the key role of NRF2 in cancer survival, progression, and chemoresistance highlights how several of its induced effects rely on the collaboration of NRF2 with oncogenic pathways, such as HSF1, mutp53, and mTOR, and with pro-tumorigenic molecules, such as p62/SQSTM1, sometimes in a feedback loop. This evidence concerns the gene SQSTM1 and cancer.