To further verify whether HMGA1 expression could modulate histone gene expression in BC cells, we evaluated the expression level of six histone genes among those that turned out to be over-expressed in BC tissues (i.e., HIST1H2BD, HIST1H4H, HIST1H2AC, HIST1H1C, HIST1H2BG, and HIST1H2BK) (Supplementary Table S1). The gene discussed is H2BC5; the disease is breast cancer.