HMGA1 can positively influence both histone H3S10 phosphorylation by ribosomal protein S6 kinase alpha-3 (RSK2) and histone H2BK5 acetylation by CREB-binding protein (CBP) regulating the expression of a set of genes involved in tumor progression and EMT [44]. This evidence concerns the gene RPS6KA3 and neoplasm.