GPT and hepatocellular carcinoma: Concerning in vivo experiments, in rats with hepatocellular carcinoma induced by diethylnitrosamine, caffeic acid (100 mg/kg) reduced the histopathological changes and normalized levels of alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bile acid, total cholesterol, HDL and LDL [28].