UCP1 and Simpson-Golabi-Behmel syndrome: Caffeic acid (5 μM, 10 μM, and 50 μM) decreased the expression of key genes of white adipogenic differentiation, including adiponectin, CAAT/enhancer-binding protein alpha (CEBPA), and fatty acid-binding protein 4 (FABP4), and increased the expression of brown adipocyte markers: cell death activator CIDE-A (CIDEA), and uncoupling protein 1 (UCP1) in human Simpson-Golabi-Behmel syndrome (SGB) adipocytes [76].