ACTR2 and triple-A syndrome: In the LEAD vs. CVD group, there were three such genes: ACTR2 (ARP2), SAMHD1, TERF2IP (RAP1), HERC2. In CVD patients (CVD vs. control group), there were two characteristic genes: HSPA1A, TRRAP; only one appeared in the LEAD vs. AAA comparison (CLK2).