They contribute to pathological cell motility, enhancing neointima formation after vascular injury (ACTR2 [89]), cerebral vasculopathy in Aicardi–Goutieres syndrome (SAMHD1 [90,91,92]) and cells’ activation, senescence and apoptosis (TERF2IP [93]). The gene discussed is SAMHD1; the disease is Aicardi-Goutières syndrome.