ERN1 and familial pancreatic carcinoma: Proliferation assays using fourteen pancreatic cancer cell lines showed a dose- and time-dependent growth inhibition by IRE1α-specific inhibitors, and subsequent cell cycle analysis showed that these IRE1α inhibitors caused growth arrest at either the G1 or G2/M phases (SU8686, MiaPaCa2) and induced apoptosis (Panc0327, Panc0403) [48].