When GNA’s effect was examined in vivo using an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model of colitis-associated cancer (CAC) established in BALB/c mice, GNA clearly suppressed colorectal tumors while also increasing the expression of CHOP and GRP78, indicating GNA suppressed tumor growth by triggering ER stress [52]. Here, HSPA5 is linked to neoplasm.