TGFB1 and diabetic kidney disease: They demonstrated that leucine-rich α-2-glycoprotein 1 (LRG1), which is one of the top upregulated genes that exerts proangiogenic effects through enhancement of TGF-β1 signaling, is localized predominantly in glomerular endothelial cells, and that its expression is elevated in the kidneys of unilaterally nephrectomized, STZ-induced DKD mice [41].