Further, co-culture of leukaemia cells with bone marrow-derived stromal cells altered the expression of ABC transporters MDR1, multidrug resistance associated protein 1 (MRP1), MRP2, MRP3 and BRCP in myeloid leukaemia cells in an insulin-like growth factor 1 (IGF1) signalling dependent manner [101]. The gene discussed is IGF1; the disease is myeloid leukemia.