CXCR4 and acute myeloid leukemia: CXCR4 expression is also associated with poor AML patient outcomes [74,75], and increased CXCR4 expression is observed in FLT3-internal tandem duplication (ITD) AML, compared with FLT3 wild-type AML [74], suggesting that the FLT3 axis may participate in the CXCR4-mediated trafficking of AML cells.