NFKB1 and acute myeloid leukemia: Whilst activation of nuclear factor kappa B (NF-κB) in myelopoietic cells, and the absence of the inhibitor IκB are not sufficient for hypergranulopoiesis, these changes in the non-haematopoietic compartment resulted in increased numbers of dysplastic haematopoietic cells with progression into secondary AML [58].