HRH3 and psychiatric disorder: As H3R has been implicated in a number of psychiatric disorders, including schizophrenia, addiction, and ADHD [28,68,75,76], further future investigations for ST-713 with its multiple-targeting profile are warranted to comprehend whether the observed enhancing effects of ST-713 are due its capability of targeting the D1-, D2-, and/or -H3R heterodimers or solely the H3Rs.