Indeed, known factors associated with AD development (ageing, genetic factors, vascular diseases), there are many hypotheses concerning AD pathophysiology, including the formation of neurofibrillary tangles of hyperphosphorylated τ-protein inside the neurons (τ-hypothesis), abnormal extracellular deposits of already mentioned amyloid β (amyloid hypothesis), oxidative stress, inflammation, alterations in brain vasculature, cholinergic neuron damage, etc. This evidence concerns the gene TBXT and Alzheimer disease.