Furthermore, our dual-color IF analysis detected frequent co-localization of 53BP1 and γH2AX nuclear foci in human follicular thyroid carcinomas (FTCs) and irradiated thyroid glands of rats, suggesting that the endogenous activation of the DDR pathway in cancer cells is a hallmark of genomic instability [16,17]. This evidence concerns the gene TP53BP1 and thyroid gland follicular carcinoma.