These include the cytokine receptor-like factor 2 (CRLF2) B-ALL subtype, which is characterized by genetic alterations in CRLF2 such as reciprocal translocation with the immunoglobulin heavy chain locus (IGH-CRLF2); and interstitial deletion within the pseudoautosomal region 1 (PAR1) regions of chromosomes X and Y juxtaposing CRLF2 with the purinergic receptor P2Y, G-protein coupled, 8 (P2RY8)-promoter (P2RY8-CRLF2). Here, CRLF2 is linked to acute lymphoblastic leukemia.