CISH and acute lymphoblastic leukemia: To determine whether TSLP contributes to the upregulation of SOCS genes, we used CRLF2 B-ALL cells isolated from the bone marrow of PDX-1 mice, treated the cells with 15,000 pg/mL TSLP ex vivo for 36 h, harvested the cells from the ex vivo culture and performed whole-genome microarray analyses.