NOS2 and mucopolysaccharidosis type 3A: For instance, oxidative stress-related genes such as the inducible nitric oxide synthase (fold change: 2.1), NADPH oxidase subunit (fold change: 2.6), superoxide dismutase 2 (fold change: 1.9), glutathione peroxidase (fold change: 2.1) were found overexpressed in the brain of MPS IIIA mice, compared with healthy animals [88], supporting the link between a pro-oxidative profile and the CNS impairment in the MPS IIIA.